St. John's Mercy Skilled Nursing Center is committed to providing skilled nursing in a healing and caring environment. Located across from the Medical Center on Conway Road, the 120-bed, not-for-profit Skilled Nursing Center provides compassionate care to meet the individual needs of each patient. It provides state-of-the-art short-term rehabilitation services such as physical, occupational or speech therapy and person-centered long term nursing care.

The Skilled Nursing Center has a low employee turn-over rate, and many co-workers from the Center have been employed with St. John's Mercy for 20 or more years. St. John's Mercy has been named among "The Best Places to to Work" by the St. Louis Business Journal, Modern Healthcare magazine, and St. Louis Magazine.